Long-term hormone replacement results in lower total homocysteine concentrations in all methylenetetrahydrofolate reductase genotypes.
Moreover, there is no demonstrable difference in effect between unopposed and opposed hormone replacement therapy (HRT), suggests a study from the Departments of Clinical Biochemistry and Endocrinology, Odense University Hospital, and the Department of Thrombosis Research, University of Southern Denmark, Odense, Denmark.
Dr. Jonna S. Madsen and colleagues aimed to investigate the long-term effect of HRT on total homocysteine and to study any difference in effect between opposed and unopposed hormone therapy or association with the methylenetetrahydrofolate reductase C677T polymorphism.
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