Weekly methotrexate is well tolerated for long-term maintenance of remission in patients with generalised Wegener’s granulomatosis.
Nevertheless, close monitoring of these patients is critical, warns a study from Germany. In the study, one-third of the patients, whether or not they were still on concomitant glucocorticoids (GC), relapsed during ongoing methotrexate (MTX) treatment. The fact that more than half of the relapses affected the kidney underscores the need for monitoring.
Dr. Eva Reinhold-Keller and colleagues from the Medical University of Lubeck, Lubeck, and the Medical School of Hannover, Hannover, Germany, did this open-label, prospective study to examine long-term efficacy of low-dose intravenous MTX, with and without GC, for remission of this condition.
השאירו תגובה
רוצה להצטרף לדיון?תרגישו חופשי לתרום!