06/13/2002 By Mark Moran
There appears to be no difference in the frequency of upper gastrointestinal complications following renal transplantation between patients on tacrolimus- and cyclosporin-based immunosuppressive regimens.
Furthermore, the complication rates appear to be similar in those receiving omeprazole or ranitidine as anti-ulcer prophylaxis, say researchers at the University Hospital of Wales and the Welsh Transplant Research Group, University of Wales College of Medicine, Cardiff, Scotland. Information on 236 patients undergoing renal transplantation between January 1996 and December 1998 was collected prospectively onto a computerized database.
Of these, 101 were placed on tacrolimus-based immunosuppressive regimens, and 135 were on cyclosporin-based regimens. One-hundred-and-eighteen of the 236 received omeprazole as anti-secretory therapy, and 118 received ranitidine.
Overall, 20 patients developed upper gastrointestinal complications, and opportunistic infections accounted for nine of the 20.
No patient developed gastroduodenal ulceration, required laparotomy, suffered graft loss or died.
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