June 11, 2002
Although supplements containing ephedra have been circumstantially linked to dangerous cardiovascular effects, results of a controlled trial reported in the June issue of the International Journal of Obesity suggest that the combination of ephedra and caffeine may safely aid weight loss.
Extrapolating these results to off-the-shelf supplements, however, could be risky. “It is surprising how people’s minds can be so made up based on anecdotal reports,” lead author Carol N. Boozer, DSc, tells WebMD. “You can’t determine cause and effect from this kind of information.”
In this six-month, double-blind trial, 167 subjects (body mass index [BMI] 31.8 ± -4.1 kg/m2) were randomized to placebo or herbal treatment at two outpatient weight-control research units. Herbal treatment consisted of ma huang and kola nut supplement containing 90 mg/day ephedrine alkaloids and 192 mg/day caffeine.
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