06/06/2002
By David Loshak
Brachial artery pulse pressure in people with type II diabetes and untreated mild hypertension is determined mainly by proximal aortic stiffness in a way which is not strongly influenced by peripheral pulse wave reflection.
About 60 percent of the variance in brachial artery pulse pressure could be explained by potentially modifiable determinants, say specialists in Amsterdam, The Netherlands.
They noted that although brachial artery pulse pressure was a predictor of cardiovascular morbidity, its determinants in people with type II diabetes and untreated mild hypertension were unclear.
The specialists therefore investigated determinants of brachial artery mean 24 hour pulse pressure in 40 males and 20 females averaging 57.8 years with both conditions.
The specialists measured three potential determinants which reflected different aspects of central artery stiffness.
These were overall systemic arterial compliance, the aortic augmentation index and 1/(regional carotido-femoral transit time).
The specialists also measured structural and functional changes of the circulatory system often seen in type II diabetes and diabetes-associated metabolic variables.
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