06/04/2002 By Anne MacLennan
Whether elevated plasma homocysteine or low vitamin B6 status directly influences pathogenesis or progression of Alzheimer disease remains to be discovered.
However, it does now appear that elevated plasma homocysteine in patients with Alzheimer disease (AD) is related to vascular disease and not to AD pathology.
Furthermore, low vitamin B6 status is prevalent in patients with AD, suggests this study from the Departments of Medical Pathology and of Neurology, University of California, Davis, School of Medicine, Sacramento, California, United States. Cerebrovascular disease is known to be a cause of dementia and is also associated with elevated plasma levels of homocysteine; unexplained elevations of homocysteine concentrations occur in AD versus healthy control subjects. Until now, vitamin B6 status, one potential determinant of plasma homocysteine, has not been characterized in AD patients.
Against this backdrop, J. W. Miller and colleagues investigated plasma homocysteine, vitamin B6 status and occurrence of vascular disease in patients with AD.
Forty-three AD patients and 37 controls without AD were studied for homocysteine, B vitamin status (folate, vitamin B12, pyridoxal-5′-phosphate [PLP]), kidney function
(creatinine) and thyroid function (thyroid-stimulating hormone, thyroxin).
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