05/20/2002 By Elda Hauschildt
Patients with early invasive cervical adenocarcinoma to a depth of three millimetres or less stromal invasion can be treated with non-radical surgery. This includes patients who meet the criteria for FIGO (International Federation of Gynaecology and Obstetrics) stage 1A1.
Researchers from the National Cancer Centre in Tokyo and the Saitama Cancer Centre in Saitama, Japan define non-radical surgery as simple extra-fascial hysterectomy without lymphadenectomy and oophorectomy. They assessed 79 patients who had been treated surgically for cervical adenocarcinomas with invasion to five mm or less.
Mean age of participants was 46 years, with a range of 29 to 73 years. Median follow-up was 118 months, with a range of nine to 348 months.
Investigators used the 1995 FIGO staging system to evaluate stromal invasion. Definitive treatment modalities for participants included: radical hysterectomy in 71 patients (89.9 percent); modified radical hysterectomy in two patients (2.5 percent); and simple extra-fascial hysterectomy without pelvic lymphadenectomy in six patients (7.6 percent). Researchers note five participants (6.3 percent) had postoperative adjuvant external radiation therapy. Histological subtypes among participants were: endocervical (37 patients or 46.8 percent); endometrioid (32 patients or 40.5 percent) and adenosquamous (10 patients or 12.7 percent).
A total of 41 patients (51.9 percent) had lesions up to three mm of stromal invasion; 38 patients (48.1 percent) had stromal invasion greater than three mm and no greater than five mm.
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