04/09/2002
By David Ball
Depressed patients who are also hypercortisolemic appear to have resistance to insulin and increased visceral fat, possibly accounting for a link between major depression and cardiovascular disorders.
In a study of 22 postmenopausal depressed women with 23 healthy controls comparing levels of free cortisol and visceral fat, the depressed patients who were also hypercortisolemic had higher levels of fat accumulation than controls. Also, the depressed patients with hypercortisolemia also had greater fat deposits than depressed patients whose cortisol levels were normal.
No difference in fat was found when comparing all patients with the healthy women, suggesting that it is hypercortisolemia in depression that accounts for the greater fat accumulation.
Researchers at the Central Institute of Mental Health , Mannheim, and the Department of Psychiatry, Free University of Berlin, Germany measured intra-abdominal fat by computer tomography at the level of lumbar vertebrae 1 (L1) and 4 (L4). Over a seven-day drug free period, saliva was taken at 8 a.m. from both patient and control groups to measure free cortisol.
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