מתוך medicontext.co.il
LONDON (Reuters Health) – Patients with cardiac syndrome X demonstrate increased platelet aggregability at rest compared with coronary artery disease patients and healthy subjects, according to a report by Italian researchers. Exercise, however, reduces platelet aggregability in syndrome X patients.
Dr. Gaetano A. Lanza and colleagues from the Universitא Cattolica del Sacro Cuore in Rome assessed platelet aggregability in 31 patients with normal coronary arteries but with angina and exercise-induced ST-segment depression typical of syndrome X, 25 patients with coronary artery disease, and 29 healthy subjects.
Platelet aggregation time was significantly shorter (p < 0.01) in syndrome X patients (83.2 s) than in patients with coronary artery disease (94.0 s) and in healthy subjects (96.4 s), the authors note in the October issue of the European Heart Journal.
Exercise prolonged platelet aggregation time in syndrome X patients by 17.4 s, shortened the time in coronary artery disease patients by 13.8 s, and did not change the time in healthy subjects.
The exercise-induced reduction in platelet aggregability may be a protective mechanism against stress-induced cardiovascular events in syndrome X patients, the researchers note. They suggest that, among patients with exercise-induced angina and ST-segment depression, the platelet response to exercise might be useful in distinguishing patients with coronary artery disease from those with syndrome X.
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