מתוך medicontext.co.il
WESTPORT, CT (Reuters Health) – Obesity may be the central feature that links the components of the metabolic syndrome, according to a report published in the October issue of Diabetes Care.
The metabolic syndrome, also known as syndrome X or insulin resistance syndrome, is a loosely defined grouping of cardiovascular risk factors. The precise definition of the syndrome and the inter-relationship of its various features have been unclear.
Dr. Nicholas J. Wareham, from the University of Cambridge in the UK, and colleagues studied 937 subjects, 40 to 65 years of age, who underwent oral glucose tolerance testing on two occasions at 4.5-year intervals. The researchers evaluated how components of the metabolic syndrome changed in this entire population and in a subgroup of 471 subjects who did not receive antihypertensive or lipid-lowering drugs.
In men, the pattern of change in components of the metabolic syndrome could be reduced to three factors: a blood pressure factor, a glucose factor, and a lipid factor. In women, an additional factor which included body mass index, waist-to-hip ratio, fasting insulin level, and triglyceride level was identified. In both sexes, change in overall obesity was central to all factors.
The current findings suggest that obesity, central obesity, and hyperinsulinemia may be essential for the development of metabolic syndrome, the authors note. Hypertension, dyslipidemia, and glucose intolerance appear to be secondary features of the syndrome.
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