מתוך medicontext.co.il
WESTPORT, CT (Reuters Health) – Despite encouraging findings from animal studies, estrogen replacement therapy appears not to retard a decline in cognitive functioning in postmenopausal women, according to a report in the American Journal of Epidemiology for October.
Dr. Suzana Alves de Moraes from Johns Hopkins University Bloomberg School of Public Health, Baltimore, and colleagues collected data on 2859 women 48 to 67 years of age who participated in the Atherosclerosis Risk in Communities Study.
The women had their cognitive functioning tested twice between 1990 and 1998, using the Delayed Word Recall Test, the Digit Symbol Subtest of the Wechsler Adult Intelligence Scale-Revised and the Word Fluency Test, according to the report.
After adjustment for confounding, no consistent change in cognition between testing was detected according to category of menopause or use of estrogen replacement therapy. This held true for current estrogen use and for the duration of estrogen use, and for women of all ages, the study group found.
These findings "would seem to indicate that, at least for women in the age range included in the study, use of estrogen replacement therapy is not associated with age-related cognitive declines," the researchers conclude.
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