מתוך medicontext.co.il
WESTPORT, CT (Reuters Health) – Women with implanted medical devices are more likely to develop undifferentiated connective tissue disease (UTCD) than women without these devices, according to a report published in the American Journal of Epidemiology for October 1.
Previous studies have failed to find a link between silicone-containing implants and specific autoimmune diseases such as scleroderma or other rheumatic diseases, the authors note. However, the statistical power of many of these studies may have been limited in that relatively rare diseases and exposures were examined.
In the current study, Dr. David Schottenfeld, from the University of Michigan at Ann Arbor, and colleagues compared the device exposure history of 205 women with UTCD with that of 2095 control women without such disease.
Women who had received any type of silicone-containing device were 2.81 times more likely to develop UTCD than women who had not received a device, the authors state. An elevated risk was noted with silicone breast implants, in particular, but the association was not significant.
Implantation of non-silicone-containing devices was also associated with a significantly increased risk of UTCD, the researchers note. In fact, women who had received artificial joints were 5 times more likely to develop UTCD than those who had not.
On average, women had received their implant at least 4 years prior to developing UTCD, the investigators point out. There was a "suggestive relation" between duration of exposure and incremental risk of UTCD.
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