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A high daily intake of coffee appears to be associated with a reduced risk of type 2 diabetes, suggest Dutch researchers.

 People who drank seven or more cups of coffee a day were 50 percent less likely to develop type-2 diabetes when compared with people who drank coffee less frequently, an average two cups a day or less, reports Dr Rob van Dam and colleagues at the Department of Nutrition and Health, Vrije Universiteit Amsterdam.

Their findings held, even when confounding factors such as smoking, alcohol consumption, and body mass, were taken into account.

Coffee is a major source of caffeine and chlorogenic acid, and contains substantial amounts of magnesium and other micronutrients, the researchers note. Metabolic studies show caffeine acutely decreases sensitivity to insulin, but tolerance of caffeine can develop.

 The phenol chlorogenic acid reduces glucose absorption and oxidative stress in vitro,1 and inhibits hydrolysis of glucose-6-phosphate, which could reduce glucose output in the liver. Magnesium intake has been associated with a lower risk of type 2 diabetes.

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