Dextrin augments haemoglobin levels in patients with iron deficiency, which often goes unrecognised during chronic haemodialysis.
Researchers from the University of Cape Town, South Africa, treated patients with haemoglobin levels of less than 10 g/dl and transferrin saturation of less than 20 percent with iron polymaltose (dextrin) by total dose infusion.
Most patients were not receiving concurrent recombinant human erythropoietin. Previous studies found that iron deficiency anaemia remains common among patients on chronic haemodialysis despite oral iron supplements.
Sixty-two of the 80 patients in the unit were iron deficient and received intravenous dextrin. No patients experienced adverse reactions. Ten patients showed iron balance and eight showed iron overload.
After three months, 53 percent of the patients that received iron polymaltose showed increased haemoglobin levels of at least 1 g/dl. Only two patients failed to respond. The remaining patients showed a less marked response to dextrin.
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