Laurie Barclay, MD Sept. 30, 2002
Frequent use of nonoxynol-9 potentiates transmission of HIV-1 but not of gonorrhea or chlamydia, according to results of a randomized trial reported in the Sept. 28 issue of The Lancet.
Although laboratory studies have suggested that this common spermicide gel might help prevent HIV-1 infection, this trial suggests that it is not only ineffective, but could actually increase HIV-1 transmission if used more than three times daily. The investigators and editorialist stress the importance of developing an effective vaginal microbicide.
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