Carvedilol, alone or in combination with standard heart failure therapy, appears to reverse chemotherapy-induced congestive heart failure.
Dr. Elizabeth Newsome and colleagues from the M.D. Anderson Cancer Center, in Houston, Texas, United States, reported the finding here September 24th at the 6th Annual Scientific Meeting of the Heart Failure Society of America. One of the serious side effects of chemotherapeutic agents such as adriamycin is congestive heart failure (CHF), which is seen in 15 percent of the patients on the drug.
“No previous clinical trials have ever been performed to evaluate the effectiveness of ACE inhibition and non-selective beta blockade in the cancer patient with CHF,” the researchers say. This is probably due to cancer patients historically being excluded from heart trials and heart patients excluded from cancer trials.
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