Photorepair of cyclobutyl pyrimidine dimers in skin varies widely between individual patients. Excision repair also varies.
Discussing photoreactivation of the dimers, researchers noted that experiments using two photorepair light sources on ultraviolet-irradiated skin showed negative results even though they induced high dimer levels.
This suggested that the additional dimers could have obscured photoreactivation. The researchers at the Department of Dermatology, Harvard Medical School, Boston, Massachusetts, United States, said the problem led them to design and validate a photorepair light source of sufficient intensity to catalyse photoreactivation but without inducing cyclobutyl pyrimidine dimers. The device was used to measure photorepair in skin.
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