The presence of immunoglobin E antibodies to distinct allergenic epitopes of cow’s milk proteins are markers for persistent cow’s milk allergy (CMA).
United States researchers say the markers might be useful in predicting life-long CMA in young children. Investigators from the Jaffe Institute for Food Allergy at Mount Sinai School of Medicine in New York City point out that cow’s milk is a common cause of food allergy in the first years of life.
They note their previous research had already defined IgE-binding epitopes for all six major cow’s milk proteins. In this study, they assessed whether recognition of IgE antibodies of certain epitopes would distinguish patients with life-long CMA from those likely to outgrow the allergy.
The researchers used sera from 10 patients with persistent CMA and 10 patients who subsequently outgrew it to investigate the differences in epitope recognition. They synthesized 25 decapeptides of the core epitopes on a cellulose-derivatised membrane, according to the known IgE-binding regions of cow’s milk proteins.
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