Omega-3 Fatty Acids Improve Systemic Arterial Compliance


Laurie Barclay, MD

July 26, 2002 — Two omega-3 fatty acids contained in fish, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), significantly improve systemic arterial compliance, according to the results of a double-blind, placebo-controlled trial reported in the August issue of the American Journal of Clinical Nutrition. As a result, systolic and pulse pressure and total vascular resistance tended to decrease, while triglyceride levels dropped significantly.

“Substantial epidemiologic and other evidence shows that eating fish may benefit people at high risk for ischemic heart disease (IHD), [and] sudden cardiac deaths occur less frequently in individuals who habitually [eat] fish,” write Paul Nestel, from Baker Medical Research Institute in Melbourne, Australia, and colleagues. “Because of increasing evidence linking heightened pulse pressure, a reflection of increased arterial stiffness, to increased coronary risk, interventions that improve arterial compliance are thought likely to reduce risk for IHD.”

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