Unlike many antiepileptic drugs (AEDs) that alter the effectiveness of oral contraceptive pills (OCP), primarily through induction of the CYP 3A4 enzyme system, levetiracetam (Keppra) does not, according to the results of a double-blind, randomized trial reported in the July issue of Epilepsia.
“Drug interactions between AEDs and oral contraceptives are a critical concern for women with epilepsy,” lead author Isabelle Ragueneau-Majlessi, MD, from the University of Washington School of Pharmacy in Seattle, says in a news release. “To date, few AEDs have been shown not to impede the effect of oral contraceptives.”
During the run-in phase of this study, 18 healthy women received an OCP containing ethinyl estradiol, 0.03 mg, and levonorgestrel, 0.15 mg, for the first 21 days of two consecutive menstrual cycles. In a subsequent double-blind, randomized, two-way crossover treatment phase, subjects received either levetiracetam, 500 mg, or placebo twice daily in addition to the OCP.
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