NEW YORK (Reuters Health) Jul 18 –
Osteoprotegerin deficiency due to a genetic mutation leads to juvenile Paget’s disease, researchers report in the July 18th issue of The New England Journal of Medicine. In an interview with Reuters Health, lead author Dr. Michael P. Whyte noted that osteoprotegerin is “the key suppressor of osteoclast formation and activation.”
Dr. Whyte, from Shriners Hospital for Children, St. Louis, and colleagues evaluated two cases of juvenile Paget’s disease seen in unrelated Navajo patients. The researchers used PCR amplification, direct sequencing and Southern blotting, of genomic DNA to look for defects in the TNFRSF11B gene, which encodes osteoprotegerin.
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