DALLAS, July 2
In a study of neighboring African tribes, a tribe eating a fish-rich diet had lower levels of the hormone leptin than a tribe eating a primarily vegetarian diet, researchers report in today’s rapid access issue of Circulation: Journal of the American Heart Association.
Leptin is secreted by fat tissue. In humans, leptin is a satiety factor, which in normal-weight people tells their bodies when they have consumed enough food. High leptin levels have been associated with obesity and increased risk for cardiovascular disease.
As people gain weight, the body may stop listening to the leptin message, so more leptin is produced, explains senior author Virend K. Somers, M.D., D. Phil., professor of medicine in the division of cardiovascular disease and hypertension at the Mayo Clinic, Rochester, Minn. However, among the African populations in this study, higher body fat was not clearly associated with increased leptin levels.
“Regardless of body fat or body mass index (BMI), leptin levels were substantially lower among the fish-eaters than among vegetarians,” says Somers. “We speculate that a fish diet may change the relationship between leptin and body fat and somehow help make the body more sensitive to the leptin message.”
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