June 27, 2002
In a population-based case-control study reported in the June 27 issue of the New England Journal of Medicine, oral contraceptives (OCP) did not increase the risk of breast cancer, even in long-term users, in women that began OCP use at a young age or in women with a family history of breast cancer.
“Current or former use of OCP among women 35 to 64 years old did not significantly increase the risk of breast cancer,” write Polly A. Marchbanks, PhD, from the Centers for Disease Control and Prevention, Atlanta, Georgia, and colleagues.
“Our data provide strong evidence that former OCP use does not increase this risk later in life, when the incidence of breast cancer is higher.” Based on interviews of 4,575 women with breast cancer and 4,682 control patients, the authors calculated the relative risk to be 1.0 (95% confidence interval [CI], 0.8-1.3) for women currently using OCP and 0.9 (95% CI, 0.8-1.0) for previous users. Relative risk did not increase consistently with longer duration of use or with higher estrogen doses, nor was it higher in black women, women with positive family history, or women who began using OCP early in life.
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