June 26, 2002
Mothers given magnesium sulfate in preterm labor were more likely to have babies with adverse outcomes, according to the results of a randomized controlled trial in the June issue of the American Journal of Obstetrics and Gynecology.
The effect was dose-related and correlated with ionized magnesium levels in cord blood, leading the investigators to suggest that magnesium sulfate should no longer be used as a tocolytic agent. “Contrary to original hypotheses, this randomized trial found that the use of antenatal magnesium sulfate was associated with worse, not better, perinatal outcome in a dose-response fashion,” write Robert Mittendorf, MD, DrPH, from Loyola University Medical Center and colleagues.
The investigators randomized 149 mothers in preterm labor to treatment with magnesium sulfate, another tocolytic, or placebo. Periodic neonatal cranial ultrasound diagnosed intraventricular hemorrhage and periventricular leukomalacia, and cerebral palsy in survivors was diagnosed at age 18 months.
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