06/19/2002
By Elda Hauschildt
Airway remodeling in asthmatic patients likely begins in childhood and continues into adult life. Canadian and New Zealand researchers say airway remodeling is manifested in asthmatics as impaired lung function and can lead to irreversible loss of lung function.
Using a low post-bronchodilator ratio of forced exhaled volume in one second (FEV1) to vital capacity (VC) at age 18 or 26 as a marker of airway remodeling, the researchers studied the impact of childhood asthma, airway responsiveness, atopy and smoking on airway remodeling in a birth cohort followed until age 26.
The investigators, from St. Joseph’s Hospital and McMaster University in Hamilton, Ontario and the University of Otago in Dunedin, studied healthy participants to determine sex- and age-specific reference values for the ratio. These participants had no history of asthma, no wheezing in the last year and had not ever smoked.
The lower limit of normal was defined as the mean ratio minus 1.96 standard deviation. This delimited the 2.5 percent of the normal population with the lowest FEV1/VC ratio.
The researchers found a low post-bronchodilator FEV1/VC ratio in 7.4 percent of asthmatic participants at age 18 and in 6.4 percent at age 26.
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