06/07/2002 By David Loshak
Sawtooth waves, an electroencephalographic pattern that forms part of rapid eye movement sleep but seems to be independent of other rapid eye movement sleep events, have their own generating mechanisms.
The dopaminergic system might play a modulating role in these mechanisms, suggest researchers in São Paulo, Brazil.
That must be the case, they argue, because rapid eye movement sleep deprivation, as well as administration of neuroleptics, produced supersensitivity of dopaminergic receptors. Sawtooth waves have a unique morphology, the researchers said. Although they are a characteristic feature of rapid eye movement sleep, little has been known about how they are generated.
The mechanisms involved seem to differ from rapid eye movements themselves. The researchers studied sawtooth waves in 10 male volunteers aged 20-35 years at a sleep laboratory.
The volunteers underwent polysomnographic monitorings on two initial nights.
On the third night, they received placebo or haloperidol and spent the whole night awake.
On the fourth night, they had a third polysomnographic monitoring.
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