Outcome is poor in patients who have had a renal transplant and who then develop colorectal cancer.
Australian researchers suggest immunosuppression and late diagnosis are both implicated in the poor outcomes. They studied characteristics and surgical outcome of colorectal cancer in 2,417 patients with chronic renal failure (CRF).
Patients were treated at one hospital between January 1967 and September 2000 either by renal transplantation or dialysis. Investigators from Queen Elizabeth Hospital in Adelaide reviewed the clinical records of the 14 participants who developed colorectal cancer. Nine of these patients had had renal transplants.
Five had been on dialysis. Of the 14 patients, eight had surgery, and three were treated through palliative chemotherapy. One patient died in hospital after surgery. Researchers had clinical notes on seven of the nine transplant patients. Six had presented with late-stage disease, and all six died of colorectal cancer within nine months.
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