Laurie Barclay, MD NEW YORK (MedscapeWire) May 16
In a retrospective study described in the May 7 issue of the Annals of Internal Medicine, aggressive treatment of thalassemia in selected patients with cirrhosis, traditionally thought to be irreversible, surprisingly showed reversibility. “In some patients in whom bone marrow transplantation has cured thalassemia, cirrhosis may be reversible after iron removal treatment,” write Pietro Muretto, MD, and colleagues from the Azienda Ospedale San Salvatore di Pesaro in Italy. Of 491 consecutive patients whose thalassemia was cured by bone marrow transplantation, 6 selected patients had incomplete or definite cirrhosis on liver biopsy and distinct improvement during follow-up.
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