מתוך medicontext.co.il
WESTPORT, CT (Reuters Health) – In patients with systemic lupus erythematosus who are treated with high-dose steroids, osteonecrosis appears to develop within 1 month after therapy is started, according to a report in the December issue of the Annals of Rheumatic Diseases.
High-dose steroid therapy is known to be linked to osteonecrosis development in SLE patients. However, the investigators note that it was unclear exactly when osteonecrosis occurs, as conventional radiographic images are not sensitive enough to detect the earliest bone changes.
Dr. K. Oinuma and colleagues from Chiba University in Japan used MRI to detect osteonecrotic lesions in 72 patients with active SLE. All of the patients had just begun high-dose corticosteroid treatment and were evaluated with MRI 1, 3, 6, and 12 months after starting therapy.
Thirty-two patients had evidence of osteonecrosis on MRI, the researchers note. On average, osteonecrotic lesions were detected 3.1 months after therapy was initiated. However, the MRI findings suggested that the actual onset of disease may have been 1 to 2 months prior to MRI scanning. No new osteonecrotic lesions were detected at 6 or 12 months.
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