מתוך medicontext.co.il
WESTPORT, CT (Reuters Health) – High magnetic fields in the vicinity of high-power electric lines appear to depress urinary concentration of 6-sulfatoxymelatonin (6-OHMS) in women who are already prone to decreased melatonin levels, two research teams report in the American Journal of Epidemiology for October.
It has been suggested that suppression of the normal nocturnal rise in melatonin production and release increases the risk of breast cancer.
Dr. Scott Davis, of the Fred Hutchinson Cancer Research Center in Seattle, and colleagues analyzed data regarding personal magnetic field exposure and complete urine samples obtained on three nights at two different seasons of the year. A total of 1106 urine samples were analyzed.
Dr. Patrick Levallois, of the Centre Hospitalier Universitaire de Quיbec in Canada, and colleagues compared 6-OHMS secretion among 221 women who lived within 150 m of a high-power line and with that of 195 women who lived more than 399 m from any power line. After adjustment for primary covariates, neither team observed evidence of significant differences in urinary 6-OHMS concentrations associated with magnetic fields.
"We were quite surprised to find that, overall, the mean levels of the melatonin metabolite was completely similar in those who live near and those who live far away from power lines. This is quite reassuring," Dr. Levallois told Reuters Health.
However, Dr. Davis's team found that the effect of magnetic field exposure was greater for women who used medications already known to affect melatonin levels, such as beta-blockers, calcium-channel blockers, and psychotropic medications. Levels of 6-OHMS decreased more at higher magnetic field levels during the summer months. These investigators also observed a trend toward increased effects of magnetic field with increasing age.
In the study by Dr. Levallois and his associates, age and high body mass index appeared to predispose women living near high-power lines to a more pronounced effect on 6-OHMS urinary concentrations.
Dr. Levallois and his associates plan to continue their research in this area. "We are going to analyze our database further to see if the incidence of sleeping disorders or depressive disorders is increased with increasing magnetic fields, and if this is happening, evaluate if it is associated with a decrease in melatonin," he said.
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